A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly.

doi:10.1016/s0016-5085(97)70018-0

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Article

A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly.

Gastroenterology - 1 Dec 1997

Bock C T, Tillmann H L, Maschek H J, Manns M P, Trautwein C

Abstract excerpt

A preS mutation derived from a patient with chronic hepatitis B virus (HBV) infection who had HBV reinfection with fibrosing cholestatic hepatitis after orthotopic liver transplantation was characterized. Sequence analysis of the HBV genome revealed two deletions and a point mutation in the regul...

Topics

Chronic Disease
Hepatitis B
Hepatitis B virus
Humans
Intracellular Membranes
Mutation
Reference Values
Viral Proteins
Virion
Virus Assembly

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