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Article

Divergent preS Sequences in Virion-Associated Hepatitis B Virus Genomes and Subviral HBV Surface Antigen Particles From HBV e Antigen-Negative Patients.

The Journal of infectious diseases - 5 Jun 2018

Peiffer Kai-Henrik, Kuhnhenn Lisa, Jiang Bingfu, Mondorf Antonia, Vermehren Johannes, Knop Viola, Susser Simone, Walter Dirk, Dietz Julia, Carra Gert, Finkelmeier Fabian, Zeuzem Stefan, Sarrazin Christoph, Hildt Eberhard

Abstract excerpt

Background: Hepatitis B virus (HBV) surface proteins (HBsAg) coat the viral particle and form subviral particles (SVPs). Loss of HBsAg represents a functional cure and is an important treatment goal. Methods: We analyzed the impact of the HBV genotypes A-E and pre-S mutations on SVP expression in hepatitis B virus e antigen (HBeAg)-negative chronic HBV-infected patients. A HBV genome harboring a preS1-deletion...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29528436
DOI: 10.1093/infdis/jiy119

Genes

LHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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