Article
Both middle and large envelope proteins can mediate neutralization of hepatitis B virus infectivity by anti-preS2 antibodies: escape by naturally occurring preS2 deletions.
Journal of virology - 20 Aug 2024
Zhang Jing, Wang Qianru, Yuan Wenqing, Li Jing, Yuan Quan, Zhang Jiming, Xia Ningshao, Wang Yongxiang, Li Jisu, Tong Shuping
Abstract excerpt
Hepatitis B virus (HBV) expresses co-terminal large (L), middle (M), and small (S) envelope proteins containing preS1/preS2/S, preS2/S, and S domain alone, respectively. S and preS1 domains mediate sequential virion attachment to heparan sulfate proteoglycans and sodium taurocholate cotransporting polypeptide (NTCP), respectively, which can be blocked by anti-S and anti-preS1 antibodies. How anti-preS2 antibodies...
Topics
- Hepatitis B virus
- Humans
- Hepatitis B Surface Antigens
- Viral Envelope Proteins
- Antibodies, Neutralizing
- Hep G2 Cells
- Sequence Deletion
- Symporters
- Protein Precursors
- Hepatitis B Antibodies
- Hepatitis B
- Genotype