Article
[A preliminary study on the heterogeneity of preS2 region in hepatitis B virus].
Zhonghua nei ke za zhi - 1 Apr 2002
Huangfu Jingkun, Dong Jing, Deng Hong, Cheng Jun, Shi Shuangshuang, Hong Yuan, Ren Ximin, Li Li
Abstract excerpt
OBJECTIVE: To investigate the mutation of the preS2 gene sequence of HBV and clarify the significance of HBV quasispecies groups in the patients with chronic HBV infection. METHODS: A set of specific primers were synthesized according to HBV DNA sequence of a Chinese strain. The preS2 gene region was amplified by PCR method from the sera of 51 patients with chronic HBV infection, and the PCR products from 5...
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