Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Movement and crevices around a sodium channel S3 segment.

The Journal of general physiology - 1 Sept 2002

Nguyen Thao P, Horn Richard

Abstract excerpt

Voltage sensing is due mainly to the movement of positively charged S4 segments through the membrane electric field during changes of membrane potential. The roles of other transmembrane segments are under study. The S3 segment of domain 4 (D4/S3) in the sodium channel Na(v)1.4 carries two negatively charged residues and has been implicated in voltage-dependent gating. We substituted cysteines into nine putative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cross-Linking Reagents
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Molecular Sequence Data

Share to Mutation

Share to Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 12198095
DOI: 10.1085/jgp.20028636
PMCID: PMC2229514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Movement and crevices around a sodium channel S3 segment.PMID 12198095Read ↗

S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor.Semantic proximity Read ↗

Role of hydrophobic residues in the voltage sensors of the voltage-gated sodium channel.Semantic proximity Read ↗

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.Semantic proximity Read ↗

Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.Semantic proximity Read ↗

Slow photo-cross-linking kinetics of benzophenone-labeled voltage sensors of ion channels.Semantic proximity Read ↗

The voltage sensor module in sodium channels.Semantic proximity Read ↗

Ion channel depolarization increases repulsions between positive S4 charges to drive activationSemantic proximity Read ↗

Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation.Semantic proximity Read ↗

The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.