Article
Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.
The Journal of general physiology - 1 Jan 2000
Li R A, Vélez P, Chiamvimonvat N, Tomaselli G F, Marbán E
Abstract excerpt
The deep regions of the Na(+) channel pore around the selectivity filter have been studied extensively; however, little is known about the adjacent linkers between the P loops and S6. The presence of conserved charged residues, including five in a row in domain III (D-III), hints that these linkers may play a role in permeation. To characterize the structural topology and function of these linkers, we neutralized...
Topics
- Animals
- Ethyl Methanesulfonate
- Indicators and Reagents
- Ion Channel Gating
- Mutagenesis
- Phenotype
- Sodium Channels