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Article

Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c.

American journal of physiology. Renal physiology - 1 Dec 2003

Tenenhouse Harriet S, Martel Josée, Gauthier Claude, Segawa Hiroko, Miyamoto Ken-ichi

Abstract excerpt

The present study was undertaken to define the mechanisms governing the regulation of the novel renal brush-border membrane (BBM) Na-phosphate (Pi) cotransporter designated type IIc (Npt2c). To address this issue, the renal expression of Npt2c was compared in two hypophosphatemic mouse models with impaired renal BBM Na-Pi cotransport. In mice homozygous for the disrupted Npt2a gene (Npt2-/-), BBM Npt2c protein...

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Identifiers

PMID: 12952859
DOI: 10.1152/ajprenal.00252.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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