Article
Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021
Beggs Megan R, Young Kennedi, Pan Wanling, O'Neill Debbie D, Saurette Matthew, Plain Allein, Rievaj Juraj, Doschak Michael R, Cordat Emmanuelle, Dimke Henrik, Alexander R Todd
Abstract excerpt
Calcium (Ca2+) homeostasis is maintained through coordination between intestinal absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re)absorption occurs via transcellular and paracellular pathways. The latter contributes the bulk of (re)absorption under conditions of adequate intake. Epithelial paracellular permeability is conferred by tight-junction proteins called claudins. However, the...
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