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Article

Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2001

Van Cromphaut S J, Dewerchin M, Hoenderop J G, Stockmans I, Van Herck E, Kato S, Bindels R J, Collen D, Carmeliet P, Bouillon R, Carmeliet G

Abstract excerpt

Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25(OH)(2)D(3)] action on calcium homeostasis. We assessed the rate of serum (45)Ca accumulation within 10 min of oral gavage in two strains of VDR-knockout (KO) mice (Leuven and Tokyo KO)...

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Identifiers

PMID: 11687634
DOI: 10.1073/pnas.231474698
PMCID: PMC60869

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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