Article
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease.
The Journal of clinical investigation - 1 Apr 2020
Curry Joshua N, Saurette Matthew, Askari Masomeh, Pei Lei, Filla Michael B, Beggs Megan R, Rowe Peter Sn, Fields Timothy, Sommer Andre J, Tanikawa Chizu, Kamatani Yoichiro, Evan Andrew P, Totonchi Mehdi, Alexander R Todd, Matsuda Koichi, Yu Alan Sl
Abstract excerpt
The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence implicates a role for defective calcium reabsorption in the renal proximal tubule. We hypothesized that claudin-2, a paracellular cation channel protein, mediates proximal tubule calcium reabsorption. We found that claudin-2-null mice have hypercalciuria due to a primary defect in renal tubule calcium transport and...
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