Article
The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.
Mechanisms of development - 1 Aug 1996
van der Lugt N M, Alkema M, Berns A, Deschamps J
Abstract excerpt
Drosophila homeotic genes and vertebrate Hox genes are involved in the anteroposterior organization of the developing embryo. In Drosophila, the Polycomb- and trithorax-group genes are required to maintain the homeotic genes throughout development in the repressed or activated state, respectively...
Topics
- Age Factors
- Animals
- Embryo, Mammalian
- Gene Expression Regulation
- Genes, Homeobox
- In Situ Hybridization
- Mice
- Mice, Inbred Strains
- Morphogenesis
- Mutation
- Nuclear Proteins
- Polycomb Repressive Complex 1
- Proto-Oncogene Proteins
- RNA
- Repressor Proteins
- Tissue Distribution