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Article

The Drosophila Polycomb group gene Sex combs extra encodes the ortholog of mammalian Ring1 proteins.

Mechanisms of development - 1 May 2004

Gorfinkiel Nicole, Fanti Laura, Melgar Teresa, García Emiliano, Pimpinelli Sergio, Guerrero Isabel, Vidal Miguel

Abstract excerpt

In Drosophila, the Polycomb group (PcG) of genes is required for the maintenance of homeotic gene repression during development. Here, we have characterized the Drosophila ortholog of the products of the mammalian Ring1/Ring1A and Rnf2/Ring1B genes. We show that Drosophila Ring corresponds to the Sex combs extra (Sce), a previously described PcG gene. We find that Ring/Sce is expressed and required throughout...

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Identifiers

PMID: 15147763
DOI: 10.1016/j.mod.2004.03.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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