Article
Control of Rad52 recombination activity by double-strand break-induced SUMO modification.
Nature cell biology - 1 Nov 2006
Sacher Meik, Pfander Boris, Hoege Carsten, Jentsch Stefan
Abstract excerpt
Homologous recombination is essential for genetic exchange, meiosis and error-free repair of double-strand breaks. Central to this process is Rad52, a conserved homo-oligomeric ring-shaped protein, which mediates the exchange of the early recombination factor RPA by Rad51 and promotes strand annealing. Here, we report that Rad52 of Saccharomyces cerevisiae is modified by the ubiquitin-like protein SUMO, primarily...
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