Article
Administration of a phorbol ester to patients with hematological malignancies: preliminary results from a phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2002
Strair Roger K, Schaar Dale, Goodell Lauri, Aisner Joseph, Chin Khew-Voon, Eid Joseph, Senzon Rachelle, Cui Xiao Xing, Han Zheng Tao, Knox Beth, Rabson Arnold B, Chang Richard, Conney Allan
Abstract excerpt
PURPOSE: Phorbol esters are capable of inducing a broad range of cellular effects,including the maturation/differentiation of hematopoietic cell lines (E. Huberman and M. F. Callaham, Proc. Natl. Acad. Sci. USA, 76: 1293-1297, 1979; J. Lotem and L. Sachs, Proc. Natl. Acad. Sci. USA, 76: 5158-5162, 1979; G. Rovera et al., Proc. Natl. Acad. Sci. USA, 76: 2779-2783, 1979; H. P. Koeffler, J. Clin. Investig., 66:...
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