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Article

Induction of B-cell chronic lymphocytic leukaemia and hairy cell leukaemia like phenotypes by phorbol ester treatment of normal peripheral blood B-cells.

British journal of haematology - 1 Jul 1990

Visser L, Poppema S

Abstract excerpt

To investigate the relationship between normal B-cells, B-cell chronic lymphocytic leukaemia (B-CLL) cells and hairy cell leukaemia (HCL) cells the three cell types were incubated with phorbol myristic acetate (PMA). The parameters studied were morphology, immunophenotype and tartrate resistant acid phosphatase (TRAP). PMA stimulation of B-cells induced morphological changes as well as CD5, CD11c, B-ly 7 and TRAP...

Topics

B-Lymphocytes
Cell Differentiation
Cells, Cultured
Humans
Leukemia, Hairy Cell
Leukemia, Lymphocytic, Chronic, B-Cell
Phenotype
Spleen
Tetradecanoylphorbol Acetate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2386770
DOI: 10.1111/j.1365-2141.1990.tb04349.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2386770-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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