Article
Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1994
Kharbanda S, Saleem A, Hirano M, Emoto Y, Sukhatme V, Blenis J, Kufe D
Abstract excerpt
The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells. Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threoni...
Topics
- Cell Differentiation
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Enzyme Activation
- Ethers, Cyclic
- Gene Expression Regulation
- Humans
- Immediate-Early Proteins
- Monocytes
- Okadaic Acid
- Phenotype
- Protein Serine-Threonine Kinases
- Ribosomal Protein S6 Kinases
- Tetradecanoylphorbol Acetate