Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1994

Kharbanda S, Saleem A, Hirano M, Emoto Y, Sukhatme V, Blenis J, Kufe D

Abstract excerpt

The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells. Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs. The EGR-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Gene Expression Regulation

Share to Phenotype

Share to Transcription Factors

Share to Transcription, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8018558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.PMID 8018558Read ↗

Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation.Semantic proximity Read ↗

Enhanced phosphorylation of STAT-1 is dependent on double-stranded RNA-dependent protein kinase signaling in HLA-B27-expressing U937 monocytic cells.Semantic proximity Read ↗

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner.Semantic proximity Read ↗

Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.Semantic proximity Read ↗

Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells.Semantic proximity Read ↗

Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells.Semantic proximity Read ↗

ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.Semantic proximity Read ↗

Characterization of the promoter region of the human PARG gene and its response to PU.1 during differentiation of HL-60 cells.Semantic proximity Read ↗

The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1.Semantic proximity Read ↗

Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module.Semantic proximity Read ↗

Induced expression of a monocytoid B lymphocyte antigen phenotype on the REH cell line.Semantic proximity Read ↗

Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.