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Article

Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.

The EMBO journal - 15 Aug 2002

Longo Letizia, Vanegas Olga Camacho, Patel Meghavi, Rosti Vittorio, Li Haiqing, Waka John, Merghoub Taha, Pandolfi Pier Paolo, Notaro Rosario, Manova Katia, Luzzatto Lucio

Abstract excerpt

Mouse chimeras from embryonic stem cells in which the X-linked glucose 6-phosphate dehydrogenase (G6PD) gene had been targeted were crossed with normal females. First-generation (F(1)) G6PD(+/-) heterozygotes born from this cross were essentially normal; analysis of their tissues demonstrated strong selection for cells with the targeted G6PD allele on the inactive X chromosome. When these F(1) G6PD(+/-) females...

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Identifiers

PMID: 12169625
DOI: 10.1093/emboj/cdf426
PMCID: PMC126165

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Source receipt: pubmed, retrieved 7 Sept 2026.

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