Article
An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2000
Nicol C J, Zielenski J, Tsui L C, Wells P G
Abstract excerpt
The primary recognized health risk from common deficiencies in glucose-6-phosphate dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis. Here we show that litters from untreated pregnant mutant mice with a hereditary G6PD deficiency had increased prenatal (fetal resorptions) and postnatal death. When treated with the anticonvulsant drug phenytoin, a human teratogen that...
Topics
- Animals
- Base Sequence
- DNA Damage
- DNA Primers
- Embryo, Mammalian
- Embryonic and Fetal Development
- Female
- Glucosephosphate Dehydrogenase
- Heterozygote
- Homozygote
- Mice
- Mice, Mutant Strains
- Oxidative Stress
- Phenotype
- Pregnancy
- Teratogens