Death before birth: clues from gene knockouts and mutations.

doi:10.1016/S0168-9525(00)89008-3

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Article

Death before birth: clues from gene knockouts and mutations.

Trends in genetics : TIG - 1 Mar 1995

Copp A J

Abstract excerpt

A survey of mouse gene knockouts, transgene insertions and spontaneous mutations that are lethal prenatally reveals that surprisingly few developmental disturbances lead to death of the embryo and early foetus. These disturbances include failure to establish and maintain a vascular circulation, a...

Topics

Animals
Embryo Implantation
Embryonic and Fetal Development
Female
Fetal Death
Gastrula
Gene Expression Regulation, Developmental
Genes, Lethal
Humans
Mammals
Mice
Mice, Knockout
Morphogenesis
Mutation

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