Article
Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice.
The Journal of biological chemistry - 13 Oct 1995
Blackburn M R, Wakamiya M, Caskey C T, Kellems R E
Abstract excerpt
Adenosine deaminase (ADA, EC 3.5.4.4) is an essential enzyme of purine metabolism that is expressed at very high levels in the murine placenta where it accounts for over 95% of the ADA present at the fetal gestation site. We have recently shown that ADA-deficient fetuses, which also lack ADA in t...
Topics
- Adenosine Deaminase
- Animals
- Embryonic and Fetal Development
- Female
- Fetal Death
- Genotype
- Liver
- Mice
- Mice, Transgenic
- Placenta
- Pregnancy
- Recombinant Proteins
- Restriction Mapping
- Weaning