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Article

Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.

Thrombosis and haemostasis - 1 Feb 2000

Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino F J, Collen D, Rosen E D

Abstract excerpt

Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette. The genotype distribution among the offspring from heterozygous breeding pairs suggested that FX deficiency resulted in partial embryonic lethality, with approximately one-third of the FX-/- embryos...

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PMID: 10739370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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