Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.

Molecular and cellular biology - 1 Sept 2005

Christie Graham R, Williams David J, Macisaac Fiona, Dickinson Robin J, Rosewell Ian, Keyse Stephen M

Abstract excerpt

To elucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice. Crossing male chimeras with wild-type females resulted in heterozygous (DUSP9(+/-)) females. However, when these animals were crossed with wild-type (DUSP9(+/y)) males none of the progeny carried the targeted DUSP9 allele,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dual-Specificity Phosphatases
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Genes, Lethal

Share to Mitogen-Activated Protein Kinase Kinases

Share to Organogenesis

Share to Placenta

Share to Protein Tyrosine Phosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 16135819
DOI: 10.1128/MCB.25.18.8323-8333.2005
PMCID: PMC1234323

Genes

DUSP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.PMID 16135819Read ↗

A parental requirement for dual-specificity phosphatase 6 in zebrafish.Semantic proximity Read ↗

Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.Semantic proximity Read ↗

Essential role of the ERK/MAPK pathway in blood-placental barrier formation.Semantic proximity Read ↗

Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines.Semantic proximity Read ↗

Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.Semantic proximity Read ↗

Methylation of Dual Specificity Phosphatase 4 Controls Cell DifferentiationSemantic proximity Read ↗

Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restrictionSemantic proximity Read ↗

Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3.Semantic proximity Read ↗

Analysis of knockout mice reveals critical female-specific roles for the Hippo pathway component PTPN14.Semantic proximity Read ↗

Analysis of Mid- to Late-Gestation Phenotypes in Mice.Semantic proximity Read ↗

Deletion of STK40 protein in mice causes respiratory failure and death at birth.Semantic proximity Read ↗

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.