Article
Death of mouse embryos that lack a functional gene for glucose phosphate isomerase.
Genetical research - 1 Jan 2000
West J D, Flockhart J H, Peters J, Ball S T
Abstract excerpt
A null allele of the Gpi-1s structural gene, that encodes glucose phosphate isomerase (GPI-1; E.C. 5.3.1.9), arose in a mutation experiment and was designated Gpi-1sa-m1H. The viability of homozygotes has been investigated. No offspring homozygous for the null allele were produced by intercrossing two heterozygotes, so the homozygous condition was presumed to be embryonic lethal. Embryos were produced by crossing...
Topics
- Animals
- Crosses, Genetic
- Female
- Fetal Viability
- Genes
- Glucose-6-Phosphate Isomerase
- Male
- Mice
- Mutation