Trans-acting RNA inhibits tRNA suppressor activity in vivo.

doi:10.1017/s1355838202026031

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Article

Trans-acting RNA inhibits tRNA suppressor activity in vivo.

RNA (New York, N.Y.) - 1 Jul 2002

Attardi Domenica Gandini, Tocchini-Valentini Glauco P

Abstract excerpt

We constructed two aptamers, each of which contains a 7-nt-long loop complementary to the anticodon loop of a suppressor tRNA. One of these aptamers can form a stable bimolecular complex with the suppressor tRNA in vitro and protects the 7 nt in the suppressor's anticodon loop from RNase S1. An Escherichia coli strain, carrying an amber mutation in the lac Z gene, produces beta-galactosidase only if the...

Topics

Anticodon
Base Sequence
Codon, Terminator
Escherichia coli
Lac Operon
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Peptide Chain Termination, Translational
RNA, Bacterial
RNA, Transfer
Suppression, Genetic
beta-Galactosidase

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Identifiers

PMID: 12166645
DOI: 10.1017/s1355838202026031
PMCID: PMC1370307

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