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Article

Suppression of nonsense mutations in cell culture and mice by multimerized suppressor tRNA genes.

Molecular and cellular biology - 1 May 2000

Buvoli M, Buvoli A, Leinwand L A

Abstract excerpt

We demonstrate here the first experimental suppression of a premature termination codon in vivo by using an ochre suppressor tRNA acting in an intact mouse. Multicopy tRNA expression plasmids were directly injected into skeletal muscle and into the hearts of transgenic mice carrying a reporter gene with an ochre mutation. A strategy for modulation of suppressor efficiency, applicable to diverse systems and based...

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Identifiers

PMID: 10757796
DOI: 10.1128/MCB.20.9.3116-3124.2000
PMCID: PMC85606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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