Article
Programmed cell death in bacteria: translational repression by mRNA end-pairing.
Molecular microbiology - 1 Sept 1996
Franch T, Gerdes K
Abstract excerpt
The hok/sok and pnd systems of plasmids R1 and R483 mediate plasmid maintenance by killing plasmid-free cells. Translation of the exceptionally stable hok and pnd mRNAs is repressed by unstable antisense RNAs. The different stabilities of the killer mRNAs and their cognate repressors explain the onset of translation in plasmid-free cells. The full-length hok and pnd mRNAs are inert with respect to translation and...
Topics
- Apoptosis
- Bacterial Proteins
- Bacterial Toxins
- Base Sequence
- DNA Mutational Analysis
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Models, Genetic
- Molecular Sequence Data
- Mutation