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Article

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.

Genes & development - 1 Aug 2002

Barolo Scott, Stone Tammie, Bang Anne G, Posakony James W

Abstract excerpt

The DNA-binding transcription factor Suppressor of Hairless [Su(H)] functions as an activator during Notch (N) pathway signaling, but can act as a repressor in the absence of signaling. Hairless (H), a novel Drosophila protein, binds to Su(H) and has been proposed to antagonize N signaling by inhibiting DNA binding by Su(H). Here we show that, in vitro, H directly binds two corepressor proteins, Groucho (Gro) and...

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Identifiers

PMID: 12154126
DOI: 10.1101/gad.987402
PMCID: PMC186408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.PMID 12154126Read ↗

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Semantic proximity Read ↗

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.Semantic proximity Read ↗

Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

Dissecting the mechanisms of suppressor of hairless function.Semantic proximity Read ↗

Hairy transcriptional repression targets and cofactor recruitment in Drosophila.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.Semantic proximity Read ↗

Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

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