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Article

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.

Development (Cambridge, England) - 1 Aug 2005

Castro Brian, Barolo Scott, Bailey Adina M, Posakony James W

Abstract excerpt

Lateral inhibition, wherein a single cell signals to its neighbors to prevent them from adopting its own fate, is the best-known setting for cell-cell communication via the Notch (N) pathway. During peripheral neurogenesis in Drosophila, sensory organ precursor (SOP) cells arise within proneural clusters (PNCs), small groups of cells endowed with SOP fate potential by their expression of proneural transcriptional...

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Identifiers

PMID: 15975935
DOI: 10.1242/dev.01920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.PMID 15975935Read ↗

Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Semantic proximity Read ↗

Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.Semantic proximity Read ↗

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.Semantic proximity Read ↗

The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila.Semantic proximity Read ↗

A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

Two modes of recruitment of E(spl) repressors onto target genes.Semantic proximity Read ↗

Neural precursor-specific expression of multiple Drosophila genes is driven by dual enhancer modules with overlapping function.Semantic proximity Read ↗

Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.Semantic proximity Read ↗

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.Semantic proximity Read ↗

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.Semantic proximity Read ↗

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