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Article

Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.

Genetics - 1 Dec 1995

Lyman D F, Yedvobnick B

Abstract excerpt

The neurogenic Notch locus of Drosophila encodes a receptor necessary for cell fate decisions within equivalence groups, such as proneural clusters. Specification of alternate fates within clusters results from inhibitory communication among cells having comparable neural fate potential. Genetically, Hairless (H) acts as an antagonist of most neurogenic genes and may insulate neural precursor cells from...

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Identifiers

PMID: 8601489
DOI: 10.1093/genetics/141.4.1491
PMCID: PMC1206882

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.PMID 8601489Read ↗

Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway.Semantic proximity Read ↗

Hairless is required for the development of adult sensory organ precursor cells in Drosophila.Semantic proximity Read ↗

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.Semantic proximity Read ↗

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction.Semantic proximity Read ↗

Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila.Semantic proximity Read ↗

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.Semantic proximity Read ↗

A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.Semantic proximity Read ↗

Novel Genome-Engineered H Alleles Differentially Affect Lateral Inhibition and Cell Dichotomy Processes during Bristle Organ Development.Semantic proximity Read ↗

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.Semantic proximity Read ↗

Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.Semantic proximity Read ↗

Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

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