Article
Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.
Genes & development - 15 Nov 1994
Van Doren M, Bailey A M, Esnayra J, Ede K, Posakony J W
Abstract excerpt
hairy (h) acts as a negative regulator in both embryonic segmentation and adult peripheral nervous system (PNS) development in Drosophila. Here, we demonstrate that h, a basic-helix-loop-helix (bHLH) protein, is a sequence-specific DNA-binding protein and transcriptional repressor. We identify the proneural gene achaete (ac) as a direct downstream target of h regulation in vivo. Mutation of a single,...
Topics
- Animals
- Base Sequence
- DNA-Binding Proteins
- Drosophila
- Gene Expression Regulation
- Genes, Insect
- Helix-Loop-Helix Motifs
- Molecular Sequence Data
- Mutation
- Peripheral Nervous System
- Repressor Proteins