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Article

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.

Molecular and cellular biology - 1 Dec 2005

Nagel Anja C, Krejci Alena, Tenin Gennady, Bravo-Patiño Alejandro, Bray Sarah, Maier Dieter, Preiss Anette

Abstract excerpt

Notch signal transduction centers on a conserved DNA-binding protein called Suppressor of Hairless [Su(H)] in Drosophila species. In the absence of Notch activation, target genes are repressed by Su(H) acting in conjunction with a partner, Hairless, which contains binding motifs for two global corepressors, CtBP and Groucho (Gro). Usually these corepressors are thought to act via different mechanisms; complexed...

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Identifiers

PMID: 16287856
DOI: 10.1128/MCB.25.23.10433-10441.2005
PMCID: PMC1291231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.PMID 16287856Read ↗

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless.Semantic proximity Read ↗

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Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

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Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless.Semantic proximity Read ↗

Hairy transcriptional repression targets and cofactor recruitment in Drosophila.Semantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

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