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Article

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

Cancer research - 1 Aug 2002

Paz Maria F, Avila Sonia, Fraga Mario F, Pollan Marina, Capella Gabriel, Peinado Miquel Angel, Sanchez-Cespedes Montserrat, Herman James G, Esteller Manel

Abstract excerpt

Aberrant DNA methylation is recognized as being a common feature of human neoplasia.CpG island hypermethylation and global genomic hypomethylation occur simultaneously in the cancer cell. However, very little is known about the interindividual inherited susceptibility to these epigenetic processes. To address this matter, we have genotyped in 233 cancer patients (with colorectal, breast, or lung tumors), four...

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Share to 5-Methylcytosine
Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cystathionine beta-Synthase

Share to Cytosine

Share to Germ-Line Mutation

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oxidoreductases Acting on CH-NH Group Donors

Source

Identifiers

PMID: 12154064

Genes

APC
BRCA1
CDH1
GSTP1
MGMT
RASSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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