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Article

Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes.

European journal of cancer (Oxford, England : 1990) - 1 Dec 2000

Esteller M

Abstract excerpt

The existence of genetic alterations affecting genes involved in cellular proliferation and death, such as TP53 and K-ras, is one of the most common features of tumour cells. Recently, gene inactivation by promoter hypermethylation has been demonstrated. Methylation is the main epigenetic modific...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11094302
DOI: 10.1016/s0959-8049(00)00303-8

Genes

BRCA1
DAP
GSTP1
MGMT
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11094302-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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