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Genetic variants of methionine metabolism and DNA methylation.

Epigenomics - 1 Jan 2014

Bleich Stefan, Semmler Alexander, Frieling Helge, Thumfart L, Muschler Marc, Hillemacher Thomas, Kornhuber Johannes, Kallweit Ulf, Simon Matthias, Linnebank Michael

Abstract excerpt

AIM: Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered DNA methylation is unknown. The methyl groups for DNA methylation are provided by methionine metabolism. This metabolism is characterized by a high interindividual variability, which is in part explained by genetic variants. METHODS: In a cohort of 313 individuals derived from a family-based...

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PMID: 25531253
DOI: 10.2217/epi.14.54

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