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Article

Roles and causes of abnormal DNA methylation in gastrointestinal cancers.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2000

Suzuki Hiromu, Toyota Minoru, Sato Hironobu, Sonoda Tomoko, Sakauchi Fumio, Mori Mitsuru

Abstract excerpt

Evidence now suggests that epigenetic abnormalities, particularly altered DNA methylation, play a crucial role in the development and progression of human gastrointestinal malignancies. Two distinct DNA methylation abnormalities are observed together in cancer. One is an overall genome-wide reduction in DNA methylation (global hypomethylation) and the other is regional hypermethylation within the CpG islands of...

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PMID: 16839207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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