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Article

CpG island methylator phenotypes in aging and cancer.

Seminars in cancer biology - 1 Oct 1999

Toyota M, Issa J P

Abstract excerpt

CpG islands are short stretches of CpG rich regions that are frequently associated with the promoter region of genes. Aberrant methylation of CpG islands is one mechanism of inactivating tumor suppressor genes (TSGs) in neoplasia, and there is growing evidence that altered cytosine methylation play important roles in cancer development. However, the differences in global CpG island methylation patterns between...

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PMID: 10547343
DOI: 10.1006/scbi.1999.0135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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