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Article

Is there a link between genome-wide hypomethylation in blood and cancer risk?

Cancer prevention research (Philadelphia, Pa.) - 1 Dec 2012

Brennan Kevin, Flanagan James M

Abstract excerpt

Cancer cells display widespread genetic and epigenetic abnormalities, but the contribution to disease risk, particularly in normal tissue before disease, is not yet established. Genome-wide hypomethylation occurs frequently in tumors and may facilitate chromosome instability, aberrant transcription and transposable elements reactivation. Several epidemiologic case-control studies have reported genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23135621
DOI: 10.1158/1940-6207.CAPR-12-0316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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