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Article

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer.

Oncology reports - 1 Jan 2006

Li Shao Ying, Rong Minna, Iacopetta Barry

Abstract excerpt

Aberrant CpG island hypermethylation in gene promoter regions may be an important epigenetic event in human neoplasias, including breast cancer. Dietary and genetic factors that alter DNA methylation levels in normal and tumour tissues could therefore influence both the susceptibility to this disease and tumour phenotype, respectively. In the present study of 227 breast cancers, we investigated whether common...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Breast Neoplasms
CpG Islands
Cystathionine beta-Synthase
DNA
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
Female
Genetic Predisposition to Disease
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Methylenetetrahydrofolate Dehydrogenase (NADP)

Methylenetetrahydrofolate Reductase (NADPH2)

Polymorphism, Genetic

Receptors, Estrogen

Receptors, Progesterone

Thymidylate Synthase

DNA Methyltransferase 3B

Source

Identifiers

PMID: 16328059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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