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DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study

1 Feb 2011

Abstract excerpt

Aberrant DNA methylation is a major epigenetic mechanism of gene silencing in a wide range of human cancers. Previous studies on DNA methylation typically used paired tumor and normal-appearing surrounding tissues from cancer-bearing individuals. However, genomic DNA isolated from surrogate tissues such as blood cells represents an attractive material that can be exploited in the discovery of biomarkers of...

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PMID: 20978370
DOI: 10.4161/epi.6.2.13573

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