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Article

Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats.

Cancer research - 1 Jun 2000

Zeng Z Z, Higashi S, Kitayama W, Denda A, Yan Y, Matsuo K, Konishi Y, Hiai H, Higashi K

Abstract excerpt

DRH strain rats were established by inbreeding a closed colony of Donryu rats continuously fed the chemical hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene for over 10 years. They are highly resistant to chemical induction of liver cancer and preneoplastic lesions. We studied the genetic basis of DRH resistance to preneoplastic lesions by analyzing 108 (F344 x DRH)F2 male rats fed...

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PMID: 10850431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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