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Article

Phenotypic reversion of rat neoplastic liver nodules is under genetic control.

International journal of cancer - 20 May 2003

De Miglio Maria R, Simile Maria M, Muroni Maria R, Calvisi Diego F, Virdis Patrizia, Asara Giuseppina, Frau Maddalena, Bosinco Giovanni M, Seddaiu Maria A, Daino Lucia, Feo Francesco, Pascale Rosa M

Abstract excerpt

Low DNA synthesis and high redifferentiation (remodeling) characterize neoplastic nodules induced by chemical carcinogens in hybrid BFF1 rats, generated by crossing the susceptible F344 and resistant BN strains. We performed whole-genome scanning of BFF2 rats to identify loci controlling remodeling of nodules induced, 32 weeks after initiation with diethylnitrosamine, by the RH protocol. Remodeling nodules were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 12672032
DOI: 10.1002/ijc.11044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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