Article
Identification of genetic loci controlling hepatocarcinogenesis on rat chromosomes 7 and 10.
Cancer research - 15 Sept 1999
De Miglio M R, Canzian F, Pascale R M, Simile M M, Muroni M R, Calvisi D, Romeo G, Feo F
Abstract excerpt
Neoplastic liver nodules and hepatocellular carcinomas (HCCs) were induced, by "resistant hepatocyte" model, 32 and 70 weeks after initiation with diethylnitrosamine, respectively, in F344 Brown Norway (BN), and (BNxF344)F1 rats. Nodule number/liver (N) did not significantly differ among rat strains, whereas nodule mean volume (V) and nodule volume fraction (VF) were higher in susceptible F344 than in resistant...
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