Article
Exploring multiple quantitative trait loci models of hepatic fibrosis in a mouse intercross.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2016
Hall Rabea A, Hillebrandt Sonja, Lammert Frank
Abstract excerpt
Most common diseases are attributed to multiple genetic variants, and the feasibility of identifying inherited risk factors is often restricted to the identification of alleles with high or intermediate effect sizes. In our previous studies, we identified single loci associated with hepatic fibrosis (Hfib1-Hfib4). Recent advances in analysis tools allowed us to model loci interactions for liver fibrosis. We...
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