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Article

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

Cell - 26 Jul 2002

Hara Kenta, Maruki Yoshiko, Long Xiaomeng, Yoshino Ken-ichi, Oshiro Noriko, Hidayat Sujuti, Tokunaga Chiharu, Avruch Joseph, Yonezawa Kazuyoshi

Abstract excerpt

mTOR controls cell growth, in part by regulating p70 S6 kinase alpha (p70alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1). Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. The binding of raptor to mTOR is necessary for the mTOR-catalyzed phosphorylation of 4EBP1 in vitro, and it strongly enhances the mTOR kinase activity toward p70alpha. Rapamycin or amino acid...

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Identifiers

PMID: 12150926
DOI: 10.1016/s0092-8674(02)00833-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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