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Article

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.

The Journal of biological chemistry - 24 Aug 2007

Fonseca Bruno D, Smith Ewan M, Lee Vivian H-Y, MacKintosh Carol, Proud Christopher G

Abstract excerpt

Signaling through the mammalian target of rapamycin complex 1 (mTORC1) is positively regulated by amino acids and insulin. PRAS40 associates with mTORC1 (which contains raptor) but not mTORC2. PRAS40 interacts with raptor, and this requires an intact TOR-signaling (TOS) motif in PRAS40. Like TOS motif-containing proteins such as eIF4E-binding protein 1 (4E-BP1), PRAS40 is a substrate for phosphorylation by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17604271
DOI: 10.1074/jbc.M704406200

Genes

TSC1
TSC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.PMID 17604271Read ↗

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GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.Semantic proximity Read ↗

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