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Article

The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.

Current biology : CB - 23 Sept 2008

Sheaffer Karyn L, Updike Dustin L, Mango Susan E

Abstract excerpt

BACKGROUND: FoxA factors are critical regulators of embryonic development and postembryonic life, but little is know about the upstream pathways that modulate their activity. C. elegans pha-4 encodes a FoxA transcription factor that is required to establish the foregut in embryos and to control growth and longevity after birth. We previously identified the AAA+ ATPase homolog ruvb-1 as a potent suppressor of...

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Identifiers

PMID: 18804378
DOI: 10.1016/j.cub.2008.07.097
PMCID: PMC2615410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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