Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.

The Journal of biological chemistry - 17 Oct 2003

Beugnet Anne, Wang Xuemin, Proud Christopher G

Abstract excerpt

The translational repressor protein eIF4E-binding protein 1 (4E-BP1, also termed PHAS-I) is regulated by phosphorylation through the rapamycin-sensitive mTOR (mammalian target of rapamycin) pathway. Recent studies have identified two regulatory motifs in 4E-BP1, an mTOR-signaling (TOS) motif in t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Genetic Vectors
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to Protein Kinases

Share to Serine

Share to Sirolimus

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 12912989
DOI: 10.1074/jbc.M308573200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12912989-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.PMID 12912989Read ↗

Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1Semantic proximity Read ↗

Identification of a conserved motif required for mTOR signaling.Semantic proximity Read ↗

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.Semantic proximity Read ↗

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.Semantic proximity Read ↗

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 bindingSemantic proximity Read ↗

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.Semantic proximity Read ↗

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.Semantic proximity Read ↗

Hierarchical phosphorylation of the translation inhibitor 4E-BP1.Semantic proximity Read ↗

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.Semantic proximity Read ↗

4E-BP1, a multifactor regulated multifunctional proteinSemantic proximity Read ↗

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.Semantic proximity Read ↗

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.