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Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth

14 Nov 2023

Abstract excerpt

The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional status and growth factors. TOR is the catalytic subunit of two distinct functional multiprotein complexes termed mTORC1 (mechanistic target of rapamycin complex 1) and mTORC2, which phosphorylate a different set of substrates and...

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PMID: 37998357
DOI: 10.3390/cells12222622

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