Article
Biased regulation of protein synthesis and hypoxic death by a conditional raptor mutation.
Current biology : CB - 9 Jun 2025
Sun Chun-Ling, Xu Cong, Itani Omar, Christensen Elyse L, Vijay Harshitha, Ho Jessica, Correa-Medina Abraham, Klingler Christian B, Mathew Neal D, Flibotte Stephane, Humphreys Ian R, Rubalcaba Diego Delgadillo, Ritter Alison E, Desbois Muriel, Grill Brock, Crowder C Michael
Abstract excerpt
Mechanistic target of rapamycin (mTOR) functions in mTOR complex 1 (mTORC1) with raptor to match metazoan metabolism to available nutrients to regulate multiple cellular, physiological, and pathological processes. Hypoxic cellular injury is influenced by the mTORC1 pathway, but whether its activity promotes or prevents injury is unclear, and which mTORC1-regulated mechanisms control hypoxic injury are obscure....
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