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Article

Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease.

Neuroscience letters - 16 Aug 2002

Bagnoli Silvia, Nacmias Benedetta, Tedde Andrea, Guarnieri Bianca Maria, Cellini Elena, Ciantelli Monica, Petruzzi Concetta, Bartoli Antonella, Ortenzi Luigi, Serio Antonio, Sorbi Sandro

Abstract excerpt

A recent study has shown that a genetic variation in the Cathepsin D (catD) gene is a major risk factor for the development of Alzheimer's disease (AD). CatD is an intracellular aspartyl protease involved in neurodegeneration. A C-->T (Ala-->Val) transition at position 224 has been associated with altered intracellular maturation. Recently, a significant overrepresentation of the T allele of the catD gene in AD...

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Source

Identifiers

PMID: 12147324
DOI: 10.1016/s0304-3940(02)00547-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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